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Saturday, November 12, 2011

The Cause of Mesothelioma

In the US, it is assumed that asbestos exposure is the major reason for noxious mesothelioma. The connection between asbestos and mesothelioma is so robust, that many consider mesothelioma a "signal tumor" meaning, it can be thought that the patient has received exposure to asbestos during their life. There are 4 major theories as to exactly how exposure to asbestos causes mesothelioma.


One such concept is that asbestos causes irritation and inflammation of mesothelial cells. This irritation can lead to irreversible scarring, cellular damage, and ultimately cancer. Another theory is that asbestos fibers disrupt the ordinary function of cellular structures that perform cellular division, which causes cellular changes that can lead to cancer. The third theory is that asbestos causes the production of oxidizing compounds which damage DNA with the end result being mutated cells that become cancerous. Lastly, the presence of asbestos has been proved to produce oncoproteins, which can cause mesothelial cells to ignore standard cellular division, leading to the development of cancer. The common thread to these 4 ideas is that asbestos causes cells to begin dividing unmanageably, ignoring their standard division cycles. The final result is cellular damage.


There are specific industries whose workers are at a ( much ) greater likelihood of mesothelioma than the population-at-large. Usually these are males above the age of 40 who have inhaled asbestos in their career. These industries include: manufacturing, shipyards, miners, military, engineers, pipe fitters, steel employees, auto engineers, and construction employees.


Unfortunately, the length of exposure required to develop asbestos is minimal, and it takes many years for the disease to surface. Studies have proved that as small as 2 to 3 months of exposure to asbestos can end up in mesothelioma 30 to 40 years down the road. The disease has also been found in family members of people who had roles that exposed them to asbestos on an everyday basis. These individuals have only secondary asbestos exposure,eg a spouse washing the clothes of her technician man.


There was significant research regarding whether or not smoking has an impact on the likelihood of developing mesothelioma. While smoking tobacco will not cause mesothelioma, smoking in conjunction with asbestos exposure significantly increases the chances of developing the illness.


In addition, mesothelioma has surfaced in some folks who were exposed to radiation in healing sessions which used thorium dioxide. Zeolite, a mineral found in the soil in certain countries such as Turkey, in addition has been linked to mesothelioma. In addition, Simian Virus 40 ( SV40 ), a product of rhesus monkey kidney cells, has been proven to prompt mesothelioma. SV40 was used to develop a polio vaccine, but it has after that been found out that the vaccine has the potential to cause growths. Prior to this discovery, millions were exposed to SV40 after receiving a contaminated polio vaccine.


Thankfully, the public is terribly mindful of mesothelioma and what causes it so likelihood of exposure is marginal in the modern-day society. However, we are going to continue to see the consequences of the utilising of asbestos for several years to come thanks to the time period it takes before symptoms appear.


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